In a large skillet over medium heat, cook the ground beef until browned, about 5-7 minutes. Drain excess fat.
Season the cooked beef with salt, black pepper, garlic powder, and onion powder. Stir to combine and remove from heat.
In a large bowl, combine the shredded lettuce, cherry tomatoes, dill pickles, shredded cheddar cheese, and red onion.
Add the seasoned beef to the salad mixture and toss gently to combine.
Drizzle the Thousand Island dressing over the salad and toss again to coat evenly.
Serve immediately or chill in the refrigerator for 15-30 minutes for a cooler dish.